Clinical studies have reported that both sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) reduce body weight and risks of major adverse cardiovascular events (MACE) and/or hospitalization for HF in patients with type 2 diabetes [10–18]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.