ACHE and Alzheimer disease: Moreover, owing to the high prevalence of Alzheimer’s dementia [193], pharmacological management of dementia (using acetylcholinesterase inhibitors, N-methyl-d-aspartate [NMDA] receptor antagonists, and combination treatment) is primarily focused on Alzheimer’s dementia, and this approach may be ineffective in treating or delaying symptoms of other types of dementia.