Under pathological conditions, including Alzheimer’s disease (AD), tau forms insoluble aggregates such as paired helical filaments and straight filaments which form the components of neurofibrillary tangles (NFT) [12, 20, 21, 32, 34, 41, 44, 47, 52, 56, 74, 80]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.