In parallel, we analyzed DNA methylation levels within the DHMRs using publicly available whole-genome bisulfite sequencing (WGBS) in healthy CD34 + hematopoietic stem progenitor cells (HSPCs) and reduced representation bisulfite sequencing (RRBS) data collected from AML patients [40] (Fig. 1G and Additional file 1: Fig. S3B, Table S2). Here, CD34 is linked to acute myeloid leukemia.