Because C/EBP-α, but not C/EBP-β, is highly expressed in MOLM13 cell (Additional file 1: Fig. S6A) and genetic lesions in C/EBP-α contribute to AML development [45], we used C/EBP-α as a proof-of-concept example to investigate the causal relationship between 5hmC and C/EBP-α enrichment in MOLM13 cell. This evidence concerns the gene CEBPA and acute myeloid leukemia.