Similar results were also showed in NAFLD mice established by MCD diet for 3 weeks that all these drugs improved liver function including ALT (Additional file 1: Fig. S9A) and AST (Additional file 1: Fig. S9B) as well as serum inflammation such as IL-1β (Additional file 1: Fig. S9C) and TNF-α (Additional file 1: Fig. S9D). The gene discussed is IL1B; the disease is metabolic dysfunction-associated steatotic liver disease.