YCHD showed potential role in treating many liver diseases, such as hepatitis, liver fibrosis and liver cirrhosis [24], and NLRP3 inflammasome takes the vital role in the process of hepatitis, liver fibrosis and liver cirrhosis in different liver diseases including NAFLD, Alcoholic fatty liver disease (ALD) and viral hepatitis [38, 39]. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.