A total of 73 genes with pearson correlation coefficient (PCC) ≥ 0.30 were found (Fig. 3A and B), in which cancer-associated chemokines CCL20, CXCL8 and CXCL3 were extremely associated with CXCL1 expression (Fig. 3C, D and E). The gene discussed is CXCL8; the disease is cancer.