To date, increasing evidence has demonstrated that the expression levels of CXCL1 and CXCR2 are frequently upregulated in several human cancers [7, 9–11], and CXCL1 may serve as a source of autocrine/paracrine signal for the malignant process in the tumor microenvironment [12, 13]. This evidence concerns the gene CXCR2 and neoplasm.