For example, secreted CXCL1 or CXCL1 overexpression in bladder cancer and melanoma was revealed to be correlated with the enhanced proliferative and metastatic properties of cancer cells, and CXCL1 in vitro was sufficient for cancer cells to generate tumors in a nude mouse xenograft model [27, 30]. This evidence concerns the gene CXCL1 and urinary bladder cancer.