Consistently, it has been suggested that CXCL1 expression was frequently upregulated in several human tumors, such as melanoma, and breast and bladder cancers, and increased expression pattern of CXCL1 was predominantly relevant to several clinicopathological features, including high grade, advanced stage, and positive invasion in bladder cancer in vivo [27–30]. This evidence concerns the gene CXCL1 and melanoma.