CX3CR1 and Alzheimer disease: While our understanding of the overarching role of microglial CX3CR1 on disease mechanisms that affect neuronal and synaptic health is still primitive, this study is the first to provide an in-vivo link between CX3CR1-dependent microglial activation, aberrant homeostasis of soluble and insoluble Aβ and subsequent effects on chronic neurodegeneration in AD.