Finally, to assess whether the loss of Cx3cr1 worsens cognitive decline, we measured spatial working memory in 6 month-old cohorts of B6 and 5xFAD mice with and without Cx3cr1. While there were no differences in total arm entries in 5xFAD;Cx3cr1+/+ and 5xFAD;Cx3cr1−/− mice, we observed a significant reduction in the number of arm entries in B6;Cx3cr1−/− mice as compared to B6;Cx3cr1+/+ controls (Fig. 7E). The gene discussed is CX3CR1; the disease is Mental deterioration.