Recent GWAS studies that have implicated CX3CR1-V249I (rs3732349), a putative loss-of-function variant previously associated with age-related macular degeneration, in worsened NFT pathology and Braak staging in AD, and neurodegeneration in ALS [6–8, 38, 49]. The gene discussed is CX3CR1; the disease is amyotrophic lateral sclerosis.