Our results indicate that Cx3cr1 deficiency exacerbates neurodegeneration and cognitive impairment with disease progression in 5xFAD animals by driving increased accumulation of neurotoxic oligomeric Aβ (oAβ), fibrillar Aβ (fAβ) plaques, intraneuronal inclusions of hyperphosphorylated tau (pTau) and enlarged foci of neuritic dystrophy. The gene discussed is MAPT; the disease is Cognitive impairment.