Compared with neuroblastoma patients with lower E2F3 expressions, 5202, 2690, 5284 and 6132 genes were significantly changed in neuroblastoma patients with higher E2F3 expressions in TARGET, GSE16476, GSE85047 and E-MTAB-1781 datasets, respectively (Fig. 8b). The gene discussed is E2F3; the disease is neuroblastoma.