On the contrary, pediatric neuroblastoma patients with age at diagnosis ≥ 18 months and with higher E2F1 expression levels had the worst event free survival and overall survival than other sub-groups in TARGET, GSE16476, GSE85047 and E-MTAB-1781 datasets (Fig. 5b and supplementary Fig. 2b). The gene discussed is E2F1; the disease is neuroblastoma.