Importantly, FGF1 was shown to exert protective effects against oxidative stress and inflammation in various disease models, including spinal cord injury (Vargas et al. 2005) and diabetic nephropathy (Liang et al. 2018), via activation of Nrf2- mediated antioxidant defense and suppression of NF-κB activation, respectively. The gene discussed is NFKB1; the disease is diabetic kidney disease.