In line with previous study, a large number of cancer cell related TFs, e.g., SMARCC1, GTF3A, MYBL2, SUB1, and NCOR1 etc., contributing to maintaining cancer cell proliferation; whereas TFs like CREB3L2, CEBPB, RUNX1 etc., playing important roles in EVT differentiation, were enriched in specific EVT subpopulations in the present study35,44,46–49. This evidence concerns the gene CREB3L2 and cancer.