The authors used two models of hypertension (angiotensin-II–induced and deoxycorticosterone acetate (DOCA)-salt–induced hypertension) and applied various ways of DEL-1 treatment including the use of endothelial cell–specific DEL-1 overexpressing mice as well as injection of recombinant DEL-1. Here, EDIL3 is linked to Hypertension.