TP53 and hepatocellular carcinoma: Down-regulation of apoptosis signaling, cell cycle G1/S checkpoint, Pten signaling; upregulation of p38 Mapk signaling, p53 signaling, mTor, Vegf, Stat3 and Erk/Mapk signaling are amongst the significantly changed pathways affected by the 38 miRNA markers in HCC mice (Fig. 3B).