Furthermore, out of the hits at a FDR of 1%, seven genes were known cancer predisposition genes36 (BRCA1, BRCA2, FANCC, MLH1, MSH2, PALB2, and APC) and at a FDR of 2% six additional cancer predisposition genes36 were identified (AXIN2, COL7A1, DIS3L2, DOCK8, SOS1, and WRN) amongst our set, suggesting that genes that affect somatic mutation processes can also confer cancer risk. Here, MSH2 is linked to cancer.