APC and cancer: Furthermore, out of the hits at a FDR of 1%, seven genes were known cancer predisposition genes36 (BRCA1, BRCA2, FANCC, MLH1, MSH2, PALB2, and APC) and at a FDR of 2% six additional cancer predisposition genes36 were identified (AXIN2, COL7A1, DIS3L2, DOCK8, SOS1, and WRN) amongst our set, suggesting that genes that affect somatic mutation processes can also confer cancer risk.