Considering known mutator genes, 0.6% had PTVs in Lynch syndrome dMMR genes (MSH2, MLH1, MSH6, PMS2), and 1.3% had PTVs in in dHR genes (BRCA1, BRCA2, PALB2, RAD51C) in the discovery cohort (TCGA). The gene discussed is BRCA1; the disease is Lynch syndrome.