Of the 11 genes identified, six (Mdm2, Rnase4, Ang (Rnase5), Abca1, Xdh, and Fth1) also showed reduced survival in both REP- and OI-SNCs (Fig. 2c, d and Supplementary Fig. 4c, d). This evidence concerns the gene ABCA1 and osteogenesis imperfecta.