Across three different cancer types (melanoma, gastric cancer, and bladder cancer), we found that NetBio-based predictions were consistently positively correlated with the proportions of anti-tumor leukocytes such as CD8 T-cell proportions, whereas the proportions of pro-tumor leukocytes, such as M2 macrophages, were consistently negatively correlated with NetBio-based predictions (Fig. 5b). This evidence concerns the gene CD8A and melanoma.