We found that the NetBio-based predictions were more accurate than predictions based on the expression levels of ICI targets including PD1, PD-L1, or cytotoxic T-lymphocyte antigen 4 (CTLA4) and markers associated with the tumor microenvironment, including CD8 T cell, T-cell exhaustion, cancer-associated fibroblast (CAF), and tumor-associated macrophage (TAM) markers. The gene discussed is CD274; the disease is neoplasm.