Single-cell transcriptome profiling reveals that bacterial infection reprograms the structure of the neutrophil population and the dynamic transition between each subpopulation.52 Abdominal sepsis-induced emergency myelopoiesis, an important source of neutrophils, is reported to be promoted by Tet2-mediated mRNA oxidation, another kind of RNA modification.18 Our RNA-seq data imply that deletion of ALKBH5 also affects the expression of other genes involved in regulation of neutrophil behavior. Here, ALKBH5 is linked to bacterial infectious disease.