Chemokine (C-X-C motif) receptor 2 (CXCR2) is a critical chemokine receptor to be responsible for neutrophil chemotaxis to infection sites, driven by its CXC chemokine ligands such as CXCL2.2,25,26 Noticeably, Alkbh5-deficient mice exhibited decreased protein expression of CXCR2 on cell surface of neutrophils from blood and bone marrow as compared to that in WT littermates, after mild CLP (Fig. 3e, f). This evidence concerns the gene CXCR2 and infection.