ALKBH5 and Sepsis: The extracellular matrix protein TNC inhibits neutrophil chemotaxis.34 WNK1 decreases neutrophil accumulation in the peritoneum of mice.35 There were increased mRNA levels of Tnc and Wnk1, reduced Il1r1 transcripts in peritoneal neutrophils from Alkbh5-deficient mice than WT littermates undergoing sepsis (Fig. 5a, b).