For example, METTL3-mediated m6A modification increases translation of certain immune transcripts for physiological promotion of DC activation and DC-based T cell response.12 Besides, METTL3 controls T cell homeostasis and differentiation by enhancing decay of Socs gene family mRNA in T cells upon IL-7 signaling.13 The expression of METTL3 in tumor-infiltrating NK cells is decreased, which contributes to the impaired NK cell infiltration and function in the tumor microenvironment.14 Yet the effect of m6A RNA demethylases on immune cells is largely unexplored. This evidence concerns the gene CISH and neoplasm.