VCAN and Sepsis: At the late stage of sepsis, the transcript levels of several neutrophil migration inhibitors, such as prostaglandin E receptor 4 (Ptger4), WNK lysine deficient protein kinase 1 (Wnk1), and Vcan, were significantly increased; while the transcript levels of multiple cytokine and chemokine receptors (such as Il1r1, Cxcr1, and Ccr7) and neutrophil-recruiting chemokines and proinflammatory factors (including Cxcl2, Cxcl3, Cxcl5, Il1a, Prok2, Csf3, Vegfa, S100a8, and S100a9)1,6 were decreased, in neutrophils from Alkbh5-deficient CLP mice (Fig. 4f).