ALKBH5 and Sepsis: The cell-surface expression of CXCR2 protein was significantly decreased on ALKBH5-deficient dHL-60 human neutrophils infected with E.coli (Fig. 5e, g), which was consistent with our in vivo results that loss of ALKBH5 declined CXCR2 protein expression on neutrophils from sepsis mice (Figs. 3e, f and 4g).