It has been proposed that neutrophils have phenotypic heterogeneity and functional plasticity in tumor, ranging from pro-inflammatory, anti-tumor ‘N1’ neutrophils to anti-inflammatory, pro-tumor ‘N2’ neutrophils.51 Does a similar plasticity of neutrophils exist at sites of bacterial infection and under control of ALKBH5? The gene discussed is ALKBH5; the disease is neoplasm.