ALKBH5 and Sepsis: Approximately 50% cecum ligation (mild CLP) can induce mid-grade sepsis, and ~75% cecum ligation-induced high-grade (lethal) sepsis is only used for testing survival.21 We found that Alkbh5-deficient mice had significantly increased mortality compared to their WT littermates when performed in a lethal form of CLP (Fig. 1g).