CXCR2 and Sepsis: Activation of G-protein coupled receptor family member PTGER4 can inhibit neutrophil migration to the inflamed sites of mice.31–33 qRT-PCR verification revealed that deletion of ALKBH5 significantly down-regulated the mRNA expression of Cxcr2 and Nlrp12, while up-regulated the Ptger4 mRNA level in peritoneal neutrophils from mice at the early or late stage of sepsis (Fig. 5a, b).