RNA-seq analysis showed that Alkbh5 deficiency in neutrophils resulted in up-regulation of 297 genes and down-regulation of 264 genes at the early stage of sepsis (Fig. 4a and Supplementary Fig. 6c), while up-regulation of 197 genes and down-regulation of 337 genes at the late stage of sepsis (Fig. 4b). The gene discussed is ALKBH5; the disease is Sepsis.