Notably, ALKBH5 deletion led to significant suppression of Cxcr2 transcripts in neutrophils (Fig. 4e), which was consistent with our in vivo observation about decreased CXCR2 protein expression on Alkbh5-deficient peritoneal neutrophils during early stage of sepsis (Fig. 4g and Supplementary Fig. 7a). This evidence concerns the gene CXCR2 and Sepsis.