Given the importance of inflammation in the pathophysiology of ALD (Marchetti et al., 2018), we investigated the effects of 72 hours exposure to PXL770 at 10 μM on the inflammatory profile in C-ALD patient’s lymphocytes, and in Abcd1 KO glial cells stimulated with TNFα and IL1β (Abcd1 KO TI). This evidence concerns the gene TNF and adrenoleukodystrophy.