In a case–control study of Chinese children, rs4674343 on CYP27A1 (27‐hydroxylase, an enzyme converting the pre‐vitamin D3 metabolite lumisterol into further downstream metabolites with biological activity in skin cells)37 was reported to be protective against atopic eczema, and CYP2R1 and VDR haplotypes also influenced atopic eczema risk and eosinophil count.38 This evidence concerns the gene CYP27A1 and atopic eczema.