In the VDAART randomized controlled trial in women at high risk of having children with asthma, the prevalence of offspring asthma at age 6 years was similar in those whose mothers received antenatal supplementation with 4400 vs. 400 IU daily vitamin D, as were the secondary outcomes of eczema and total IgE levels.10, 23, 24. The gene discussed is IGHE; the disease is asthma.