In light of these clinical and preclinical observations, the objectives of the current study were first to establish the association between plasma HS levels and plasma Ang-2 levels in children with sepsis and in mouse models of sepsis and, second, to evaluate the role of HS as a mechanotransducer and regulator of Ang-2 expression via AMPK signaling. This evidence concerns the gene PRKAA1 and Sepsis.