The insulin using group had longer duration of diabetes, higher HbA1c, history of severe hypoglycemia (all P < 0.001), and greater fear of hypoglycemia than the noninsulin using group (P < 0.001).33 Therefore, automated insulin delivery systems use in T2D present an excellent regimen modality to not only improve glucometrics, but also to reduce hypoglycemia regardless of the HbA1c levels. The gene discussed is INS; the disease is diabetes mellitus.