In this context, inhibition of PKC-β by LY333531 (0.05 μM) has been shown to attenuate the deleterious impact of ischaemic injury and hyperglycaemia on endothelial integrity and BBB function (Shao and Bayraktutan 2013; Mathur and Bayraktutan 2016). This evidence concerns the gene PRKCB and Hyperglycemia.