Several case-control studies revealed that Pro12Ala variant of PPARG in East Asia (Japanese) (Mori et al., 2001), Greater Middle Eastern (Motavallian et al., 2013) and in the populations with European lineages such as Czech (Pintérová et al., 2004), Scottish (Doney et al., 2004) and Finnish (Douglas et al., 2001) reduces the risk for developing T2D. This evidence concerns the gene PPARG and type 2 diabetes mellitus.