During early EBV infection, the EBV genome is packaged into virions and enters human cells; the entire genome is nonmethylated, Cp and Qp are in the off state, and Wp is in the on state (Belleau et al. 2018; Ling et al. 1993; Ponnusamy et al. 2019). The gene discussed is CP; the disease is Epstein-Barr virus infection.