The gene set that prioritised COL4A3 for severe DKD was the fibulin 2 protein–protein interaction network (‘FBLN2 PPI subnetwork’), which together with 26 correlated reconstituted gene-sets makes up the ‘basement membrane’ meta-gene set derived in Marouli et al [28] (ESM Table 6). This evidence concerns the gene COL4A3 and diabetic kidney disease.