CXCL8 and infection: Otherwise, the PEDV variant 85-7C40, with variation in the TM domain of the protein E (Table S3), also activated higher expression levels of inflammatory factors (interleukin [IL]-6 and IL-8, etc.)on Vero and MARC-145 cells, indicating that the 85-7C40 strain was an appropriate model to explore the characteristic of inflammatory response regulated by PEDV infection.