PRKN and Parkinson disease: In contrast to rodent mutants for PINK1 and Parkin, human blood macrophages isolated from PD patients with PARKIN mutations exhibit an overactivation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome upon administration of potent inflammatory stimulators, such as lipopolysaccharide-nigericin or lipopolysaccharide-ATP [33].