Furthermore, incorporating cytokine receptors such as IL‐15 or IL‐7 receptors or proinflammatory cytokines into CAR‐based immune cell constructs can be used to reprogram the immunosuppressive TME and extend the survival of CAR‐T and CAR‐NK cells in the hostile TME of breast cancer.207, 208, 209. Here, IL15 is linked to breast carcinoma.