Unlike CAR‐T cells, which only inhibit tumour cells by detecting tumour‐specific antigens (TAAs) and CAR‐related mechanisms, CAR‐NK cells can also spontaneously eradicate malignant cells through a variety of their native activating receptors, including natural cytotoxicity receptors (NKp46, NKp44, and NKp30), natural killer group 2 member D (NKG2D), and DNAM‐1or CD226, and their innate ability to detect stress‐stimulated ligands on tumour cells.32 The gene discussed is CD226; the disease is neoplasm.