We also measured the expression of α‐SMA by BMDMs and found that after the stimulation of TGF‐β1, BMDMs upregulated the expression of α‐SMA (Figure 6J,K ), which indicated that macrophages could present myofibroblast‐like phenotype and promote the progression of renal fibrosis. Here, ACTA1 is linked to renal fibrosis.