The differential burden of OTUD7A and CHRNA7 is well exemplified by a recent report describing a boy and a girl, each carrying two contiguous 15q13.3 microdeletions involving CHRNA7 and displaying very different clinical phenotypes: the boy has severe cognitive impairment and hyperactivity, while the girl had mild language deficits and a high IQ (Alsagob et al., 2019). Here, OTUD7A is linked to Cognitive impairment.