Our study illustrated that serum cortisol was associated with dyslipidemia (TC, TG, HDL-C, and LDL-C), impaired glycometabolism (β cell function, FPG, HbA1c, and fasting insulin) but not with SBP and DBP and weight-related indictors (BMI) in T2DM patients. This evidence concerns the gene INS and metabolic syndrome.