Although consensus clinical guidelines recommend confirming a diagnosis of AGHD with a GH stimulation test, in an appropriate clinical context, before considering GH replacement therapy, [12] AGHD can also be accurately predicted through the presentation of multiple pituitary hormone deficiencies (≥3) in the presence of low serum age- and sex-adjusted insulin-like growth factor-I (IGF-I) [13]. The gene discussed is IGF1; the disease is hypopituitarism.