Studies have reported that lipase (LPS) can mediate the production of TNF-α, IL-6, and IL-8 in patients with liver cancer via the TLR4/MyD88/NF-κB signaling pathway and activate the cyclooxygenase-2/prostaglandin signal axis, thus regulating the proliferation of liver cancer cells [18]. The gene discussed is PTGS2; the disease is liver cancer.