Previous studies have shown that a deficiency in NOD2 or NLRP6 results in a colitogenic microbiota that can exacerbate DSS-induced colitis, and the aggravated colitis phenotype exhibited by NOD2−/− or NLRP6−/− mice could be transferred to WT mice by cohousing [33, 34]. The gene discussed is NLRP6; the disease is colitis.