Furthermore, the individual classes of drugs that constitute BGF therapy have been associated with positive effects in pulmonary vasculature cells, in which they have been reported to affect molecules (e.g., nitric oxide (NO) or vascular endothelial growth factor (VEGF)) and processes (e.g., vasodilation, angiogenesis, and vascular cell proliferation) related to pulmonary vascular tone and vascular remodeling, suggesting their potential benefit in treating PH, specifically COPD-PH [12–15]. Here, VEGFA is linked to chronic obstructive pulmonary disease.