MBTD1 and osteosarcoma: For instance, lncRNA TTN-AS1 regulated osteosarcoma cell apoptosis as well as drug resistance through the miR-134-5p/MBTD1 pathway [12]; lncRNA SNHG4 sponged miR-377-3p to aggravate osteosarcoma cell proliferation as well as migration [13], and lncRNA BE503655 inhibited the osteosarcoma cell malignancy via Wnt/beta-catenin pathway [14].