Besides, we confirmed that the apoptosis of HL-60 and Molm13 cells treated with AraC + sh-MEG3 was prominently inhibited, whereas cell viability was promoted, and opposing tendency was witnessed upon AraC + oe-MEG3 treatment (Fig. 1F, Gand Additional file 6: Fig. S1D, E), indicating that MEG3 affected the sensitivity of AML cells to AraC. The gene discussed is MEG3; the disease is acute myeloid leukemia.