Additionally, Western blot analysis results (Fig. 2I and Additional file 7: Fig. S2E) presented that downregulation of miR-493-5p in parental cells reduced the levels of Bax and cleaved caspase-3 and increased Bcl-2 level, but upregulated miR-493-5p in resistant cells reversed these results, suggesting that intervention of miR-493-5p affected the sensitivity of AML cells to AraC. The gene discussed is CASP3; the disease is acute myeloid leukemia.