We screened the antitumoral activity of ipatasertib and taselisib in five breast cancer cell lines, MDAMB231, MDAMB468, MCF7, SKBR3 and MDAMB361, each one having different expression of ER and HER2 receptors, or mutations involving PI3K/AKT and BRAF/RAS pathways. This evidence concerns the gene ESR1 and breast carcinoma.