Since autophagy confer stress tolerance to mantain tumor cell survival upon PI3K-AKT/mTOR inhibitors treatment [4, 23, 49] we next tested if CQ was able to potentiate the antitumor effect of both ipatasertib and taselisib in TNBC MDAMB231 and MDAMB468 cells. The gene discussed is AKT1; the disease is neoplasm.