ADAMTS1 and pachyonychia congenita: Promoter DNA methylation of ADAMTS1 and BNC1 was significantly associated with PC in a cohort of 123 patients with PC, 20 patients with pancreatic intraepithelial neoplasia and 30 patients with pancreatitis, with sensitivities of 79% and 48% and specificities as high as 92% and 89%, respectively.