In multivariable Cox regression analysis, increasing age, transglottic tumor site, PTHrP positive and PTH1R negative tumors retained an independent prognostic significance of increased risk of recurrence, while, high III-IV stage and PTHrP positive and PTH1R negative tumors behaved as independent prognostic indicators of increased risk of death (Fig. 3). Here, PTH1R is linked to neoplasm.