In fact, in lung carcinoma, the expression of amino and carboxyl regions of PTHrP can vary independently in different tumor cases, so that the presence of amino PTHrP and PTH1R worsen the prognosis in lung cancer patients [32], while, carboxyl PTHrP, when present, may lower the stimulatory effect of amino PTHrP [50]. This evidence concerns the gene PTH1R and lung carcinoma.