Adding IL-6 and YKL-40 significantly increased the area under the ROC curves for the prediction models of Essen Stroke Risk Score (0.03, P < 0.0001) and Totaled Health Risks in Vascular Events Score (0.07, P < 0.0001), as well as resulted in continuous net reclassification index (19.0%, P < 0.0001; 33.0, P < 0.0001) (Table 4). Here, IL6 is linked to stroke disorder.