In the multivariate model, such correlation of YKL-40 with recurrent stroke persisted in these two stroke subtypes (adjusted HR 1.46; 95% CI 1.03–2.06; P = 0.03 and HR, 1.89; 95% CI 1.12–3.18; P = 0.02, respectively), while no statistical significance received for IL-6 (Additional file 1: Table S11). The gene discussed is CHI3L1; the disease is stroke disorder.