S100B and colorectal carcinoma: Interestingly, co-treatment of HCT-8 CRC cells with EntF* and Nef-M1 restored E-cadherin expression to control levels (Fig. 2c, Additional file 13): E-cadherin levels increased from 62% (EntF* only) to 94% (EntF* + Nef-M1) (Cohen’s d = 1.4).