Altogether, our findings demonstrate that the quorum sensing peptide metabolite EntF* (1) is naturally present in biofluids of mice, (2) promotes CRC metastasis in an orthotopic animal model, and (3) acts as an agonist-ligand in the CXCR4/EGFR phosphorylation/ERK activation/E-cadherin pathway with a biological activity comparable to that of EGF and CXCL12, well-established human CRC growth factors. This evidence concerns the gene EGFR and colorectal carcinoma.