Abbreviations: L-HIIT, laboratory (supervised) high intensity interval training; H-HIIT, home-based (unsupervised) HIIT; CON, no-intervention control group; BMI, body mass index (kg/m2); AT, anaerobic threshold (ml/kg/min); VO2 peak, peak oxygen uptake (ml/kg/min); SBP, systolic blood pressure (mmHg); DBP, diastolic BP; BPH, benign prostatic hyperplasia; HTN, hypertension; HCL, hypercholesterolaemia; OA, osteoarthritis; ACE, angiotensin converting enzyme; Ca+, calcium; SSRI, serotonin re-uptake inhibitor. This evidence concerns the gene ACE and osteoarthritis.