KEGG anaysis showed that proteins interacting with PIK3R3 were enriched in the ErbB signaling pathway, proteoglycans in cancer, prolactin signaling pathway, chemokine signaling pathway, insulin signaling pathway, focal adhesion, chronic myeloid leukemia, bacterial invasion of epithelial cells, FoxO signaling pathway, and pathways in cancer (Fig. 6B). This evidence concerns the gene INS and chronic myelogenous leukemia, BCR-ABL1 positive.