PIK3R3 and ovarian cancer: PIK3R3 is a relatively sensitive marker for predicting the effect of Avastin® treatment on patients with ovarian cancer based on relapse-free survival at 6 months (area under the curve [AUC] = 0.809, P = 2.2E-02) (Fig. 2A) and pathological response (AUC = 0.664, P = 3.1E-02) (Fig. 2B).