BRCA1 and breast cancer: Moreover, a recent case-only study by Coignard et al. [24] comprising more than 60,000 unselected BC cases and 13,000 cases with BRCA1/2 mutations, provided evidence that several SNPs associated with BC risk in the general population, and are therefore considered in PRS calculations, are in fact associated with the BRCA1/2 mutation status, and hence do not have effects on BC risk in BRCA1/2 PV carriers.