Standardized overall BC and ER+ BC PRSs showed a strong correlation at the individual level (BRCA1 PV carriers: Spearman’s correlation coefficient ρ=0.98 (95% confidence interval (CI): 0.97–0.98); BRCA2 PV carriers: ρ=0.99 (95% CI: 0.98–0.99), Fig. 1). This evidence concerns the gene BRCA1 and breast cancer.