When adding the clinical characteristics into multivariate logistic regression analysis, the same imaging characteristics above and two more clinical characteristics, alpha fetoprotein (AFP) > 20 ng/ml (OR 39.68, 95% CI 12.38–127.17) and male (OR 4.55, 95% CI 1.85–11.12) were independent risk factors for diagnosis of HCC and were utilised to build the clinical model (Table 3). The gene discussed is AFP; the disease is hepatocellular carcinoma.