For example, when a liver nodule has only one of the three major features of HCC, all of the ancillary features (male gender, AFP > 20 ng/ml, and TNSI) must be met to diagnose HCC, and if a liver nodule has met all of the three major features, only one of the ancillary features is needed to diagnose HCC. Here, AFP is linked to hepatocellular carcinoma.