In a previous study of factors associated with suboptimal DI in the same population, we found that late referral and rapid eGFR loss were independent predictors of suboptimal DI and that patients with suboptimal DI were more uremic at DI as judged by eGFR, had more electrolyte disturbances over and above what would be expected from the level of eGFR, and had a higher CRP [28]. The gene discussed is CRP; the disease is Abnormal blood ion concentration.