Other studies reported upregulated METTL14 expression in renal biopsy samples from patients with DN and HG-induced glomerular endothelial cells and advanced glycation end product-induced podocytes, and METTL14-dependent m6A modification of Sirt1 and α-klotho mRNA contributes to podocyte and glomerular endothelial cell injury, respectively [52, 53]. The gene discussed is SIRT1; the disease is liver dysplastic nodule.