These results agree previous observations showing that suppression of HS3ST2 in a zebrafish model of tauopathy expressing human tauP301L leads to tauopathy arrest and animal functional recovery28 and comfort the hypothesis that HS3ST2 participates to the cell autonomous P-tau oligomerisation and aggregation process in which intracellular 3S-HS might play a central role22. This evidence concerns the gene MAPT and tauopathy.