Additional proteins with schizophrenia rare variant associations (via the SCHEMA consortium62–64) altered in 22q11.2del neurons included DNM3, MAGI2 and TRIO (downregulated in patient neurons) and HIST1H1E, SRRM2 and ZMYM2 (upregulated in patient neurons) (Supplementary Data 21). The gene discussed is TRIO; the disease is schizophrenia.