TMPO, Ki67, CyclinD1 and MTA1 were expressed at higher levels in the TMPO-AS1-high group than in the TMPO-AS1-low group (Fig. 7a, b), confirming the promoting effects of TMPO-AS1 on TMPO expression and ESCC progression. The gene discussed is TMPO; the disease is esophageal squamous cell carcinoma.