Mechanistically, TAS1 recruited FUS and p300 to the TMPO promoter and formed condensates in situ, which upregulated TMPO expression by increasing the deposition of H3K27ac in the promoter and activating TMPO transcription in cis, subsequently regulating the expression of CyclinD1 and metastasis-associated protein 1 (MTA1) to promote ESCC progression. Here, MTA1 is linked to esophageal squamous cell carcinoma.